Michael J Petris Selected Research

P-type ATPases

12/2019	Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.
1/2017	Host and Pathogen Copper-Transporting P-Type ATPases Function Antagonistically during Salmonella Infection.
1/2016	Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network.
9/2010	Altered microglial copper homeostasis in a mouse model of Alzheimer's disease.
10/2007	Phenotypic diversity of Menkes disease in mottled mice is associated with defects in localisation and trafficking of the ATP7A protein.
2/2004	Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A; MNK). Endocytosis of the Menkes protein.
2/2004	The SLC31 (Ctr) copper transporter family.
11/2002	Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate.
11/2002	A conditional mutation affecting localization of the Menkes disease copper ATPase. Suppression by copper supplementation.

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Michael J Petris Research Topics

Disease

14	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2020 - 11/2002
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 12/2012
4	Neoplasms (Cancer) 01/2022 - 01/2019
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2016 - 02/2004
3	Inflammation (Inflammations) 01/2022 - 10/2012
3	Infections 01/2020 - 04/2012
3	Hepatolenticular Degeneration (Wilson's Disease) 01/2016 - 11/2002
3	Bacterial Infections (Bacterial Infection) 04/2014 - 12/2009
2	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2019
2	Carcinogenesis 06/2020 - 01/2019
2	Sialadenitis 10/2017 - 10/2012
2	Seizures (Absence Seizure) 11/2015 - 06/2015
2	Spinal Muscular Atrophies of Childhood (Werdnig Hoffman Disease) 06/2015 - 01/2012
2	Alzheimer Disease (Alzheimer's Disease) 04/2014 - 09/2010
2	Acrodermatitis enteropathica 03/2007 - 03/2004
1	Dacryocystitis (Dacryoadenitis) 01/2022
1	Starvation 01/2021
1	Squamous Cell Carcinoma of Head and Neck 06/2020
1	Mouth Neoplasms (Oral Cancer) 06/2020
1	Body Weight (Weight, Body) 12/2019
1	Carcinoma (Carcinomatosis) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/2017
1	Salmonella Infections (Salmonellosis) 01/2017
1	Demyelinating Diseases (Demyelinating Disease) 11/2015
1	Ataxia (Dyssynergia) 11/2015
1	Intellectual Disability (Idiocy) 11/2015
1	Muscle Hypotonia (Hypotonia) 06/2015
1	Failure to Thrive 06/2015
1	Muscular Atrophy (Muscle Atrophy) 06/2015
1	Peptic Ulcer (Peptic Ulcers) 03/2015
1	Melanoma (Melanoma, Malignant) 03/2015
1	Fibrosis (Cirrhosis) 01/2015
1	Disease Progression 06/2013
1	Amyloid Plaque 09/2010
1	Hypoxia (Hypoxemia) 05/2009
1	Deficiency Diseases (Deficiency Disease) 03/2007

Drug/Important Bio-Agent (IBA)

24	CopperIBA 01/2022 - 11/2002
9	P-type ATPasesIBA 12/2019 - 11/2002
6	Proteins (Proteins, Gene)FDA Link 12/2019 - 11/2002
5	Copper-Transporting ATPasesIBA 12/2019 - 10/2007
4	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 11/2002
4	Copper Transport ProteinsIBA 01/2017 - 01/2012
3	NucleotidesIBA 06/2020 - 10/2012
3	EnzymesIBA 01/2019 - 10/2007
2	Superoxide DismutaseIBA 01/2021 - 05/2009
2	CytokinesIBA 01/2015 - 06/2013
2	ZincIBA 03/2007 - 03/2004
1	MetalsIBA 01/2022
1	Purinergic Receptors (Receptors, Purine)IBA 01/2022
1	Phenolsulfonphthalein (Phenol Red)IBA 01/2022
1	AR-C118925IBA 06/2020
1	Indicators and Reagents (Reagents)IBA 06/2020
1	Uridine Triphosphate (UTP)IBA 06/2020
1	Fura-2 (Fura 2)IBA 06/2020
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2020
1	Purinergic P2Y2 ReceptorsIBA 06/2020
1	ErbB Receptors (EGF Receptor)IBA 06/2020
1	elesclomolIBA 01/2020
1	Transferrin (beta 2 Transferrin)IBA 01/2020
1	Insulin (Novolin)FDA Link 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 12/2019
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2019
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2019
1	Carbachol (Carbastat)FDA Link 10/2017
1	3- (5- (2,3- dichlorophenyl)- 1H- tetrazol- 1- yl)methylpyridineIBA 10/2017
1	Purinergic P2X7 ReceptorsIBA 10/2017
1	N-Methylaspartate (NMDA)IBA 11/2015
1	Proton Pump InhibitorsIBA 03/2015
1	Omeprazole (Prilosec)FDA LinkGeneric 03/2015
1	4- (5- benzo(1,3)dioxol- 5- yl- 4- pyridin- 2- yl- 1H- imidazol- 2- yl)benzamideIBA 01/2015
1	CollagenIBA 01/2015
1	4- (4- (3- (pyridin- 2- yl)- 1H- pyrazol- 4- yl)pyridin- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)benzamideIBA 01/2015
1	Fibronectins (Fibronectin)IBA 01/2015
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2015
1	AllergensIBA 04/2014
1	GTP-Binding Proteins (G-Protein)IBA 04/2014
1	Actin Depolymerizing Factors (Cofilins)IBA 06/2013
1	Peptides (Polypeptides)IBA 09/2010
1	Amyloid (Amyloid Fibrils)IBA 09/2010
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 05/2009
1	Ceruloplasmin (Ferroxidase)IBA 05/2009
1	zinc-binding protein (zinc binding protein)IBA 03/2004
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2002

Therapy/Procedure

2	Therapeutics 01/2021 - 06/2020
1	Denervation 06/2015
1	Ligation 01/2015